Synthesis of Hydroxybenzodiazepines with Potential Antioxidant and Antifungal Action

Benzodiazepines derivatives are nitrogen heterocyclic compounds that have various industrial, synthetic, and medicinal applications. Therefore, its potential fully justifies every effort towards the improvement of new, selective, competent production these compounds. The novelty this study encompasses synthesis new hydroxylated analogs 1,5-benzodiazepine together with evaluation their biological as antioxidants antifungals candidates. Additionally, reported antifungal activity against fungi Sporothrix schenckii complex inaugurates an unprecedented property for class results activities assays suggest novel 2,7-dimethyl-2,4-bis(4-hydroxyphenyl)-2,3-dihydro1H-1,5-benzodiazepine possesses a high all fungal strains evaluated genus outstanding total antioxidant capacity. Besides, in silico studies evidenced best aqueous solubility cell permeability profile, which makes them superior comparison commercial itraconazole, drug commonly used treatment sporotrichosis.